Posted by PaulB on August 14, 2001, at 17:05:56
In reply to Re: Questions (Serzone, NE and ADD) » MM, posted by Mitch on August 14, 2001, at 8:24:10
> > How does Serzone (SNRI's) affect Norepinephrine (basically does it raise it or lower it or what does it do, in non technical language)? What role does Norepinephrine play in ADD? If I had a better response to Serzone over SSRI's, does this suggest ADD?
>
> MM,
>
> It does increase it (NE) somewhat, but from what I have read that effect is rather mild (in contrast to the serotonin it increases) and tends to wear with time. Nearly any med that raises NE or dopamine levels can be helpful for
> ADD or ADHD.
>
> Serzone is an SSri, it just isn't as "selective" (the NE boost, etc.) What you may be finding about Serzone that you like (in contrast to the "other" SSri's) is its ability to reduce *agitation*. The other ones tend to make it worse (for me anyway). That could be why it may seem to be effective for "hyperactivity" It also reduces anticipatory anxiety quite well. I think this has more to do with its 5-HT2a antagonism (sorry for getting technical-but that is what makes it quite different from the other SSri's).
>
> I personally liked it for generalized anxiety, and I slept well on it and my agitation was reduced significantly-but I got to itching on it and it was stopped. Some people may find it an good alternative anti-panic agent.
>
> hope this helps,
> MitchI wouldnt say that because you had a better response to Nefazdone over the SRRI's(or SSRI) that you had ADD. I would look at your symptoms rather than response to medication. I thought dopamine, which Nefazadone does not enhance is indicated more in ADD.
One paper I have on Nefazadone describes that it exerts it action by:
'inhibtion of pre-synaptic reuptake of serotonin, weak inhibition of noradrenaline and strong antagonism of post-synaptic 5-HT2 receptors'Given Nefazadone weak norepinephrine activity I wouldnt read too much into it.
Good luck
PaulB
poster:PaulB
thread:75032
URL: http://www.dr-bob.org/babble/20010814/msgs/75077.html