Posted by ben on August 15, 2001, at 2:39:20
In reply to You know w/in 1-4 weeks if a med works for u, posted by Cressida on August 14, 2001, at 17:11:47
Hi thanks for your input
I think you can not generalize if someone needs a low or a high dose of the right drug ! It is often usual to rise the dosage too keep effectivness...that was the case with this girl.
Efexor works dual (serotonin and noradrenaline) only if you go over 150 mg/day. When you go over 300 mg then it works on dopamine too. Adding an SSRI to Efexor is not so usual because anyone thinks its enough serotonin lifting or too much. On the other hand it could be possible that adding an SSRI leads to shift the Efexor more to noradrenaline reuptake because the serotonine receptors are satured (competitive binding). I know this is sound very theoretical but its a try worth.> > Over the years I have noticed a trend that people who do real well with whatever medicine usually only need small doses. That's because the med is hitting a bullseye. People who don't do so well require massive doses, where they would probably be a lot better off finding a better drug instead.
>
> I think someone has made an exceptionally valid statement. If an individual must take the maximum recommended drug dosage to realize any ameliorating affect, then it might be the wrong drug. I believe most psychological disorders, especially ADD/ADHD and depressive disorders, respond positively in 1-4 weeks to psychotropic medication. Something to consider: the risks are probably greater than the benefits when the maximum dosage is reached, or when a patient is treated with multiple drugs. Simplify, simplify, simplify!
poster:ben
thread:75069
URL: http://www.dr-bob.org/babble/20010814/msgs/75118.html