Posted by Mitch on August 9, 2001, at 23:45:17
In reply to Re: Topamax Experiences re: nerve pain, posted by bob on August 9, 2001, at 18:04:43
> > Hi everybody. Nothing too exciting here.
> > I had to back down to 50 mg/day because of
> > urinary stone formation. Wearing a prosthesis
> > in hot weather is a tremendous heat stress and
> > I am awash in sweat all day. Since the stone
> > episode, I have backed down, and drink a minimum
> > of 6 liters a day to make sure I stay hydrated.
> > I also drink cranberry juice to reduce the pH.
> > It was not my idea of a fun time. Incidentally,
> > my level of pain relief at 50 vs 75, does not seem to be significantly different. Again, I
> > I did notice some iritability, but could attribute it to a reaction to the heat stress.
>
> ********************
>
> I attained a 250mg level of Topomax, and got more and more irritable along the way. It was the medecine, without a doubt. At the end, I became aggressive and angry, while at other times despondent. I had to taper down some. Then I had a kidney stone attack. I spent 24 hours at the hospital passing a 4.5mm stone. When I was there, they found 3 more stones in that kidney, and another in the other kidney. They broke up the large stone in the kidney with 3, and luckily, the other two were jostled out with it, although not without significant pain. I am still carrying the other one since it is too small for ultrasound. It causes me pain sometimes. When my p-doc learned about my hospital visit, he ordered me to taper off the Topomax immediately and quickly, and completely. It was a VERY mentally destabilizing odyssey of terror and pain. For some reason, I was extremely sensitive to Topomax, and especially to dose level changes. I guess you could say it wasn't for me.
>
> BobBob, et al,
Tegretol and Trileptal have carbonic anyhydrase inhibitor activity which can also result in kidney stones as well. If anyone is sensitive to this problem they should also avoid these two meds as a result from a switch from Topamax.
Mitch
poster:Mitch
thread:50878
URL: http://www.dr-bob.org/babble/20010809/msgs/74417.html