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Re: Gabapentin » MM

Posted by SalArmy4me on July 30, 2001, at 23:43:00

In reply to Re: mixed episode? » sar, posted by MM on July 30, 2001, at 23:36:31

Gabapentin for Mixed Episodes:

Botts, Sheila R.. Raskind, Jackie. Gabapentin and lamotrigine in bipolar disorder. American Journal of Health-System Pharmacy. 56(19):1939-1944, October 1, 1999:

"...McElroy et al. treated nine patients with bipolar disorder with adjunctive gabapentin therapy (1600-4800 mg/day orally) in an open-label study. All the patients were being treated as outpatients, were inadequately responsive to standard mood stabilizers (anti-depressants, antipsychotics, benzodiazepines, valproic acid), and were displaying persistent manic, hypomanic, or mixed symptoms. Eight of the nine patients had mixed symptoms, and six had rapid cycling. Seven patients demonstrated a moderate or marked reduction in manic symptoms one month after the addition of gabapentin therapy. One other patient had a moderate reduction after three months. Six patients maintained their antimanic response for one to seven months..."


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