Posted by pellmell on July 20, 2001, at 12:00:12
In reply to Re: MORE about this subject: HELP! » pellmell, posted by Janelle on July 19, 2001, at 21:44:12
> Woops! Well, now I'm confused, because I was under the impression that while there is only one type of serotonin *reuptake pump*, it pumps out the Serotonin to many receptors (I was told this by a doc and have also seen pictures wherein a bunch of little Serotonin circles being released from one set of receptors into the synapses, then starting to binding to a corresponding bunch of receptors on the other side so to speak).
>Yep, but the SSRIs don't control which receptors serotonin binds to once it's released from the serotonergic nerve cell's axon. Some other antidepressants though, such as Remeron, do, via receptor blockade.
> Which article that Sal cited cites evidence of what you said about the differing side-effects vs. the differing therapeutic effects? I would like to double check that one.
>It's the article he cited in this thread, which describes a study that demonstrated that most of the patients in the study who couldn't tolerate Prozac had fewer problems tolerating Zoloft.
> As for what you said about how it doesn't seem likely that a *non*-responder to one SSRI would respond to a different one, since their primary actions are the same, I know, have read and heard of MANY people (myself being one!) who have been NON-responder to one SSRI but DID indeed respond to another.
>Okie. Like I said, *I* didn't have any antecdotes to tell to back up my guess. Now you've given me some negative evidence, which is very cool (you learn more when people disagree civilly with you. ;) ).
Cheers,
-pm
poster:pellmell
thread:70936
URL: http://www.dr-bob.org/babble/20010720/msgs/71061.html