Posted by SalArmy4me on July 19, 2001, at 18:06:38
In reply to Re: Paroxetine, Sertraline,....then Fluvoxamine?, posted by Janelle on July 19, 2001, at 17:59:11
http://www.acnp.org/g4/gn401000105/
"Substituting One Serotonin Reuptake Inhibitor for Another
The proliferation of different SRIs begs the question of their interchangeability. Should patients nonresponsive to one SRI receive a trial of another or should they be routinely switched to another class of agents? As of yet, there are no controlled studies to address this important question. Clinical experience suggests that intolerance to one SRI does not necessarily convey intolerance to the whole class. A large prospective study by Brown and Harrison (11) found that 91% (85 of 93) patients intolerant to fluoxetine were able to complete an adequate trial of sertraline (50 to 200 mg/day), of which 69 (76%) responded. There are, as of yet, no controlled data to address the equally important question about the effectiveness of an alternate SRI when another member of this class is not effective..."
--My problem is not the intolerance of the SSRI's but unresponsiveness.
poster:SalArmy4me
thread:70936
URL: http://www.dr-bob.org/babble/20010714/msgs/70943.html