Posted by Lupercal on July 6, 2001, at 8:59:05
In reply to Re: Remeron - less sedation at higher dose? » Lupercal, posted by Elizabeth on July 6, 2001, at 0:22:31
> I'm not sure what "new breed of SSRIs" you're talking about. SSRIs increase the available amount of serotonin, which acts as an agonist at all serotonin receptors (by definition < g >).That isn't the way I understood it. Remeron is an agonist, but I thought SSRI's action - inhibiting re-uptake - was a different type of action. Remeron, as I understand it, causes more serotonin to be produced, and therefore its effects on receptor sites would be indiscriminate (actually it wouldn't have any effects on them: they would just have more serotonin to deal with), but SSRI's don't affect the amount of serotonin being produced; they affect the amount of it which is eliminated. Sorry if I'm wrong about this. But if that's correct, and they act by inhibiting re-uptake at serotonin sites, I don;t see why it's logically impossible for them to discriminate between which sites they affect. For example, Celexa is already more selective than Prozac in that it targets fewer non-serotogenic sites.
NB I did find a medical webpage tonight which, in relation to tinnitus, states that tinnitus is a more likely side-effect in AD's with a serotogenic action. And indeed, the T has gone very high today, after increasing the Remeron to 30mg. However I also had major dental surgery yesterday with lots of screaming drills and bonde-conducted noise (noise will make tinnitus worse for most sufferers), so it may have been that. My money is on the Remeron though, unfortunately. I'm going to stop taking it, see if the T diminishes, then give it one last trial, in case it was the drilling after all.
(I hope stopping it dead after 2 days is ok, but there's no-one down here who knows a thing about it to guide me)
NB I noticed an odd side effect with Remeron, which I've not noticed with any other AD. On going to bed last night, when the lights were out, my vision was flickering: the illumination in the room would flicker, then dim suddenly, like someone turning down the brightness on a monitor. Then it would return suddenly to normal. Did this about 20 times. Wasn't noticeable in full illumination.
Tim
Can you tell me anything more about the drugs you're thinking of?
poster:Lupercal
thread:68802
URL: http://www.dr-bob.org/babble/20010701/msgs/69164.html