Posted by SalArmy4me on July 1, 2001, at 14:10:55
In reply to Re: Giving up, posted by Joe Schmoe on July 1, 2001, at 12:48:53
I think you may want to take a look at venlafaxine because of this passage, which claims that a dual-action antidepressant works faster than a single-action AD like fluoxetine or nefazodone:
Nierenberg, Andrew A. M.D et al. Timing of Onset of AD Response With Fluoxetine Treatment. Amer J of Psychiatry. 157(9):1423-1428, September 2000:
"...The timing of onset of clinical improvement with the selective serotonin reuptake inhibitors (SSRIs) fluoxetine, sertraline, paroxetine, and citalopram, as well as with bupropion, trazodone, nefazodone, and mirtazapine, has been studied less extensively than the timing of improvement with the older generation of tricyclic antidepressants and monoamine oxidase inhibitors. Head-to-head studies of SSRIs and tricyclic antidepressants have indicated parallel improvements when measured by standard depression scales (8-11). In addition, on the basis of the hypothesis that combined norepinephrine and serotonin uptake inhibition causes a more rapid down-regulation of beta adrenergic receptors than with norepinephrine alone (12), Nelson and colleagues (13) found that combining fluoxetine and desipramine resulted in faster antidepressant effects than with desipramine alone. With a similar line of reasoning, that dual action speeds up response, a faster onset of action has been reported for venlafaxine than for SSRIs..."
poster:SalArmy4me
thread:68599
URL: http://www.dr-bob.org/babble/20010701/msgs/68622.html