Posted by Elizabeth on June 15, 2001, at 9:22:31
In reply to Re: More about list » Elizabeth, posted by Kaysey on June 15, 2001, at 8:53:13
> Thank you Elizabeth. I really need to take the time and look at more journal articles re this subject. As you said, it is difficult to extrapolate results of animal studies to human response. The animals in such studies are usually genetically pure, in a fixed environment, have the same exposures, etc. Certainly not true for us humans!!
The other thing is that you simply can't assume that the dose will be the same (even the dose per unit weight) because of potential differences in metabolism, uptake into the CNS, etc.
> It would seem though that the mg/kg measure would be a pretty good indicator--based on that I would need (assuming I could get the adrenergic effect at all) an intake in the upper 200s (getting close to 300), and that seems probable.
That's probably a reasonable range, but psych drug effects don't seem to vary so much with people's body size, probably because we're only looking for effects above the neck (central effects, that is). That's why the recommended doses for antidepressants aren't given in mg/kg.
-elizabeth
poster:Elizabeth
thread:66464
URL: http://www.dr-bob.org/babble/20010612/msgs/66546.html