Posted by Kaysey on June 15, 2001, at 8:53:13
In reply to Re: More about list » Kaysey, posted by Elizabeth on June 15, 2001, at 0:07:04
> > As always thanks (to both of you) for the valuable information. I have a question that has been addressed before, but the responses have varied. At what (approximate) dosage does the norepinephrine effect 'kick in' for effexor. I have seen everything from 200mg up to over 300 (and that it might be different for effexor vs. bvXR). Ditto that question for the dopamine effect (have seen everything from 250 mg up to 600!). Perhaps this is also something that varies greatly by individual; but is there a designated baseline for each?
>
> One study compared a group receiving 75 mg to one receiving 375 mg. At the former dose, Effexor appears to have some effects on norepinephrine reuptake but is mainly a serotonin reuptake blocker; at the latter dose, there is a clear-cut norepinephrine effect. One observation has been that the NE effect becomes more relevant at about 1 mg/kg.
>
> Unfortunately, it's hard to measure transporter binding directly in human beings, so most of the information on Effexor's dose-related effects comes from animal research. It's not always the case that animal doses in mg/kg can be translated to human doses.
>
> Dopamine reuptake inhibition occurs to a clinically significant extent only at very high doses that I would expect to be hard to tolerate for most people. It is doubtful that this action contributes much to the efficacy of Effexor.
>
> -elizabethThank you Elizabeth. I really need to take the time and look at more journal articles re this subject. As you said, it is difficult to extrapolate results of animal studies to human response. The animals in such studies are usually genetically pure, in a fixed environment, have the same exposures, etc. Certainly not true for us humans!!
It would seem though that the mg/kg measure would be a pretty good indicator--based on that I would need (assuming I could get the adrenergic effect at all) an intake in the upper 200s (getting close to 300), and that seems probable.
Thanks again!
poster:Kaysey
thread:66464
URL: http://www.dr-bob.org/babble/20010612/msgs/66545.html