Posted by SLS on June 3, 2001, at 19:50:30
In reply to Re: Studies: New Celexa+others promising » Mitch, posted by Rick on June 3, 2001, at 15:18:52
> > "Since E-10-OH-NT has been shown to be devoid of side effects when previously administered to humans, this substance is clearly to be considered of interest for potential development into a new antidepressant."
> The fact that this study came out during a period when SSRI's were mushrooming -- and Lilly had to protect cash cow Prozac -- couldn't have helped. Also, competitors could play up the bad press about tricyclics, even if a refined version lacked the side effects and potential lethal overdose hazards. Etc., etc.
That really, really, really sucks. Really.Actually, I am quite angry right now. As I think about it, this drug could have ended up being the best of the TCAs. Seeing as how I respond better to nortriptyline than any of the others, I feel particularly cheated. I would be even more pissed were I to discover that E-10-hydroxynortriptyline is without the same finicky therapeutic window that nortriptyline has. Capitalism. Is there a better way?
With regard to the r-fluoxetine ICE Prozac, Lilly could have elected to resubmit it for approval using data from a new set of studies using lower dosages, but that would have set back the project another two to three years. They elected to dump it in favor of investing money into the development of duloxetine. This also sucks.
- Scott
poster:SLS
thread:64685
URL: http://www.dr-bob.org/babble/20010530/msgs/65283.html