Posted by PaulB on May 19, 2001, at 12:33:21
In reply to Remeron, posted by laurai01 on May 19, 2001, at 10:34:48
> I have extreme nighttime anxiety/insomnia. My doctor
> is talking about Remeron. I have tried everything
> else in the psychopharm universe and this seems to be
> a last resort. The Neurontin was a weird, horrible
> experience.
>
> I have read that Remeron is only effective for about
> 1 month? Is this true? What's everybody's experience?
>
> Help!I have never been on Remeron but read about it. Its an interesting antidepressant, in so far as its mechanism of action is concerned. It blocks noradrenaline and serotonin auto-receptors which are the feedback receptors that control how much NE or 5-HT is released. By blocking these receptors they give the brain negative feedback, meaning your brain thinks there is less 5-HT and NE in the brain so fires more of these neurotransmitters. Unlike other convnetional antidepressants it does not make the supply of the monoamines available for a longer period of time. Consequence-This may burn out the supply of these neurotransmitters hence why it may only be effective for a month in some cases. There will always be options for treatment-refractory depression. If you know whats the biological root of the problem Im sure the guys and gals at this board will be able to offer you some positive suggestions.
poster:PaulB
thread:63606
URL: http://www.dr-bob.org/babble/20010515/msgs/63621.html