Posted by Chris A. on May 11, 2001, at 13:06:29
In reply to Re: Tamoxifen - experience with as a mood stabilizer?, posted by SLS on May 10, 2001, at 21:44:38
Thanks for all your thoughts. My left brain doesn't work very well so I can't organize intelligent responses to all of your queries.
In the links to grand rounds there is a lecture Manji gave entitled "Molecular mechanisms underlying mood stabilization in Manic - Depressive illness." (March 5th). I did find papers of his on medline. Most of it is above my head, but I do get the gist of it, that Tamoxifen is a PKC inhibitor like lithium and depakote. As far as gender differences go, I know nothing. I haven't even studied the PDR info yet.
Since I am not doing too badly at the moment other than vegetating and getting upset once in a while (knock on wood) my next step will probably be to add galantamine for my cognitive difficulties and then to add ziprasidone with whatever beta blocker required as the need arises. If I can handle the akathisia it is probably my best bet since is supposed to have AD effects.
Side effects often leave me taking meds at sub-therapeutic doses. Often I wish that Lithium had worked and ADs didn't cause me to cycle. Stabilization has been possible, but it has always been on the very low end of the spectrum - not acceptable.Perhaps you can suceed in getting me to think!
Blessings (and thanks for the prayers),
Chris A.
> Which paper are you referring to?
> Scott
poster:Chris A.
thread:62381
URL: http://www.dr-bob.org/babble/20010507/msgs/62489.html