Posted by SLS on March 31, 2001, at 10:33:51
In reply to Re: If Zyprexa BLOCKS dopamine, what good is it? » Eric, posted by Sunnely on March 30, 2001, at 23:56:34
> Ziprasidone (Geodon) has a strong potential for antidepressant effect due to the following receptor affinities: 1) potent serotonin 1A receptor agonist (enhancer), 2) potent serotonin 1D receptor antagonist (blocker), and 3) moderate serotonin (5HT) and norepinephrine (NE) reuptake inhibitor, similar to imipramine (Tofranil).
Dear Sunnely,Are the magnitudes of reuptake inhibition for NE and 5-HT by Geodon comparable to imipramine (IC50)?
Hmmm.
I was thinking of adding Geodon to my current regimen that includes Parnate 80mg and nortriptyline 100mg. I have taken a combination of Parnate 120mg and imipramine 300mg in the past. My concern here is that Geodon will increase the potential for untoward effects, although I have not yet experienced any with my current combination.
I will say this, though, while taking Parnate 120mg, I took the teeniest, tiniest little nibble of a tablet of Effexor. I wanted to test the potential for serotonin syndrome. I was desperate. I chose Effexor because if something nasty happened, its short half-life would quickly terminate the trial. How smart I was to choose Effexor. How stupid I was to try Effexor. Major serotonin syndrome. I became incoherent and babbled nonsense. My body temperature rose, but did not exceed 100 degrees F. I couldn't get myself to move when I tried to get out of bed. I am not sure if this was because of some sort of vertigo or because of any hypertonia. I think it was vertigo. I had to know.
Thanks for any feedback regarding Geodon.
Two more last questions. What do you think of using Moban in the role of augmentor for depression? What is its potential for EPS and TD?
- Scott
poster:SLS
thread:57880
URL: http://www.dr-bob.org/babble/20010327/msgs/58205.html