Posted by Cam W. on March 20, 2001, at 8:59:21
In reply to Could my medicine be causing this?, posted by ItsJustMe on March 20, 2001, at 0:26:43
IJM - Yes, the amitriptyline will make you groogy and lethargic, especially for the first month, during dose titration. This is due to the blocking of histamine H-1 receptors and muscarinic/anticholinergic M-1 receptors. Most people to adjust to these side effects, but the adjustment to these start-up side effects takes longer with the TCAs (like amitriptyline) than with the SSRIs (like Paxil or even Effexor).
Hope this helps - Cam
poster:Cam W.
thread:56958
URL: http://www.dr-bob.org/babble/20010319/msgs/56969.html