Posted by JohnX on February 12, 2001, at 4:42:44
In reply to Re: Re; psychopharmacology of lamictal, posted by AndrewB on February 11, 2001, at 23:51:02
> Excess sodium channel activity due to hyperglutaminnergic action can cause desensitization of the dopamine receptors in the VTA which seemingly through interconnecting pathways negatively effects mood and motivation via the nucleus accumbuns and the medial prefrontal cortex. Lamictals' actions, in part at least, may due to its ability to inhibit hyperglutaminergic activity. Wider implications are that mood stabilizers in general are able to prevent the AD poop out and mania of bipolars by stabilizing glutaminergic activity.
>
> AndrewB
Any idea why Lamictal would show more of an
antidepressant effect than say Depakote, which
also blocks sodium channels and reduces the
excitation of glutamate? Of course Depakote
also does a job interfering with calcium
channels and enhancing gaba.-John
poster:JohnX
thread:53739
URL: http://www.dr-bob.org/babble/20010212/msgs/53791.html