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Re: AmisUlPiRiDe: questions for JohnL CarolAnn

Posted by JohnL on December 1, 2000, at 4:29:29

In reply to Re: AmisUlPiRiDe: questions for JohnL, posted by CarolAnn on November 30, 2000, at 19:00:37

> Hey JohnL! Well, I'm on week four of Adrafinil, and can't see much difference, BUT I am going thru some intense circumstances which may be skewing things. Anyway, re: amisulpride - what class of drug is it? any dietary restrictions or medicine interactions?
> thanx yet again for your most excellent help! CarolAnn

CarolAnne,
Since you are already taking Adrafinil, I like the idea of adding Amisulpride to it. I know I've said it here many times, but for me either Amisulpride or Adrafinil are just OK, but together they are magic. No idea why. In your shoes, knowing what I know now as I look back, I would stay on Adrafinil and get some Amisulpride to add to it. Don't dump the Adrafinil just yet, not until you've tried adding Amisulpride to it for about 4 weeks.

No diet restrictions. No drug interactions I'm aware of, since I've combined it experimentally with a variety of different things. It is in the antipyschotic class. But unlike most APs, it has two personalities. At low doses (25mg to 100mg) it acts primarily as a slightly stimulating antidepressant by enhancing dopamine function, especially good if symptoms are anhenonia, apathy, low motivation, social anxiety. At high doses it acts like an antipsychotic. Compared to other meds you've tried, Amisulpride will likely seem almost as mild as candy in terms of side effects.

But again, I wouldn't ditch the Adrafinil. I can't emphasize it strongly enough...the two drugs together work tons better than either alone. Try it and see! :-) Hopefully you'll get the same good response I have. There's a chance you might not, but I'm optimistic you will like this combination. Just for the record, I also take a tiny dose of Prozac (5mg or 10mg per day). It never helped me much by itself, but it does seem to enhance the Adrafinil in particular.
John


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