Posted by anita on October 29, 2000, at 19:03:06
In reply to Re: Prozac+Zyprexa Special for Treatment Resistence, posted by AndrewB on October 28, 2000, at 2:54:09
Hi Andrew,
Zyprexa and Risperdal are supposed to further boost serotonin levels in ppl who are already taking SSRIs by antagonizing the 5HT2A receptor, which adds to the SSRI effect on 5HT1A receptors, and it also increases dopamine in an area of the prefrontal cortex. Then again, some say the antipsychotics work simply because they increase the blood level of the SSRI or make it work more effectively. This might be the case for the special synergy with prozac, as prozac is a relatively messy drug and can increase norepinephrine and dopamine as well as serotonin. This could also be why Zoloft only increased dopamine levels, since zoloft only affects serotonin and dopamine.
I don't know if low doses of Zyprexa and Risperdal increase dopamine other than thru their 5HT2A antagonism.
anita
> Thank for the info., I found this abstract provocative. I would be curious to see the whole article. What was the suspected underlying mechanism for this underlying synergy? All the antipsychotics they listed effect certain serotonin receptors as well as dopamine receptors. Also, were the antipsychotics used at low dosages at which they would be presumably acting on dopamine autoreceptors. I wonder if this article sheds any light on whether SSRIs can be effectively combined with sulpiride or amisulpride, dopamine specific antipsychotics.
>
> AndrewB
poster:anita
thread:47361
URL: http://www.dr-bob.org/babble/20001022/msgs/47711.html