Posted by JohnL on October 25, 2000, at 17:22:21
Hi all. I was doing a little research at www.mentalhealth.com and stumbled onto this interesting study. Just thought I would pass it on. It seemed interesting and intriguing. It's amazing how different each medicine is. Anyway, it seems Prozac + Zyprexa have some unique synergy that isn't duplicated with Zoloft or other antipsychotics. Something unique about this combo. For whoever's interested.
John1: Neuropsychopharmacology 2000 Sep;23(3):250-62
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Synergistic effects of olanzapine and other
antipsychotic agents in combination with fluoxetine on
norepinephrine and dopamine release in rat prefrontal
cortex.Zhang W, Perry KW, Wong DT, Potts BD, Bao J, Tollefson GD,
Bymaster FPNeuroscience Research Division, Lilly Research Laboratories, Lilly
Corporate Center, Indianapolis, IN 46285-0510, USA.To understand the mechanism of the clinical efficacy of olanzapine and
fluoxetine combination therapy for treatment-resistant depression (TRD),
we studied the effects of olanzapine and other antipsychotics in
combination with the selective serotonin uptake inhibitors fluoxetine or
sertraline on neurotransmitter release in rat prefrontal cortex (PFC) using
microdialysis. The combination of olanzapine and fluoxetine produced
robust, sustained increases of extracellular levels of dopamine ([DA](ex))
and norepinephrine ([NE](ex)) up to 361 +/- 28% and 272 +/- 16% of the
baseline, respectively, which were significantly greater than either drug
alone. This combination produced a slightly smaller increase of serotonin
([5-HT](ex)) than fluoxetine alone. The combination of clozapine or
risperidone with fluoxetine produced less robust and persistent increases
of [DA](ex) and [NE](ex). The combination of haloperidol or MDL
100907 with fluoxetine did not increase the monoamines more than
fluoxetine alone. Olanzapine plus sertraline combination increased only
[DA](ex). Therefore, the large, sustained increase of [DA](ex),
[NE](ex), and [5-HT](ex) in PFC after olanzapine-fluoxetine treatment
was unique and may contribute to the profound antidepressive effect of
the olanzapine and fluoxetine therapy in TR
poster:JohnL
thread:47361
URL: http://www.dr-bob.org/babble/20001022/msgs/47361.html