Posted by medlib on October 19, 2000, at 21:27:09
In reply to DOES THIS MAKE SCENTS??, posted by Sharon J. on October 18, 2000, at 9:30:46
Sharon--
That's definitely a scary reaction. I doubt that it's due to viral infection; most URI's lead to DEcreased sense of smell. 2 possibilities you might want to investigate further with your doctor (I am NOT one) --
1) Hyperosmia is one of several possible prodromal symptoms (meaning, they precede the onset) of migraine headaches. If your doc is unfamiliar with hyperosmia, you could ask him for referral to a neurologist. If hyperosmia IS linked to migraines, medication that resolves the headache should relieve it, too. (Also, feeling inert, exhausted is a frequent aftermath of severe migraines.)
2) Topomax *has* caused parosmia (disturbed sense of smell) in clinical trials. Rx lit lists its incidence as "infrequent" (btw.1/100 and 1/1000). IMHO, such statistics are susceptible to understatement, and don't matter much anyway, when the 1 is YOU. BTW, Topo can also cause migraines.
The only other things I know that might be remotely relevant are...
1) New olfactory neurons are produced approx. every 60 days. So if, worst case, topo has damaged some nerves, time *might* ameliorate the problem some (although my own hyposmia seems pretty permanent).
2) Olfactory nerves connect to the hippocampus, the hypothalamus, and the amygdala (all brain centers which have a connection to moods).
3) Psych drugs can, over time, cause changes in neuroreceptors which last longer than the presence of those drugs in the body.Hope a bit of this helps. Well wishes---medlib
P.S. I'm trusting that the experts here (and we have many!) will correct any misstatements I may have made. Thanks, all.
>Hi. I just discovered this page tonight as I searched the web for some answers to some questions I have, so maybe someone out there has an answer for me. I have been taking Topomax in gradual 25 mg dose increases in one-week to 10-day intervals, aiming toward a therapeutic level of 200 mg (where we would stay for a min. of 6 months) for treatment of lability. I, too, have been losing weight, and in this period of time, have dropped 32 pounds! However, I have a couple of problems that occurred that I want to share that happened to me to see if anyone out there could offer any clues to a mystery. As the dosage of my Topomax was increased, each increase became more and more diffucult to adjust to, and took more and more time before I got to an OK place. (I was feeling dull, lethargic, lack of motivation and kind-of headachey, and these side effects increased intensity and duration at 100mg, 125mg). When I reached the increase from 125 mg to 150 mg, it was just terrible. I felt almost disabled by it, and felt generally sick all over, and was exhausted physcially (but not sleepy), and my head felt wierd. Almost 2 1/2 weeks later, I still had not made the adjustment to 150 mg, and Dr. said to "hang in there". That increase and it's adjustment period seemed endless in comparison to the others, and then a few more days later, something really odd happened: I developed a very sudden onset of hyperosmia (exaggerated and increased sense of smell) coupled with the nastiest case of physical collapse, exhaustion and terrible headache! Within several more days of the hyperosmia onset, I began having panic attacks, GI problems, difficulty staying asleep at night and physical revolt to normal household smells. I vaccillated between severe physical distress from the reaction to "smells" to long periods of being total inert for many, many hours, trying to recover from the extreme physical and emotional manifestations as a result of my hyperosmia! I got really scared and "blamed" Topomax. In the last 10 days, Dr. dropped the dosage of the Topomax (at my insistence) even though he disagreed with me that it caused me to be so sick. Nonetheless, he safely and swiftly reduced the Topomax. It has been 48 hours that I have been Topomax-free, and I am still as sick and miserable as when the hyperosmia started (Oct. 4). I have been to see my physician 3 times since the onset, and he sees "nothing" in my nasal cavities, said I probably have a virus or something, and said he never had a patient present hyperosmia to him before, and admitted he's stumped. I admit I have a really strong aversion to ever taking Topomax again, especially since I am still so sick. I really think this all started as my Topomax dosage increased to 150mg! I need to find out what made me get so sick and caused the hyperosmia. So...anybody out there ever have a wierd reaction to Topomax like this, or can you make 2 + 2 = 4 for me on this one??? Or better yet, any psychopharmacologists or neurologists have any input as to whether there is any remote possibility that Topomax can upset the balance in the brain where the olfactory lobes(?) live? On second thought, how about disputing this scientifically for me so I can get over my intense fear of what Topomax "did" to me altogether? I am grasping for straws. Thanks for any input y'all might have!
poster:medlib
thread:46666
URL: http://www.dr-bob.org/babble/20001012/msgs/46819.html