Posted by JohnL on October 10, 2000, at 5:04:54
In reply to I need help playing doctor . . ., posted by James (I do a mean Elvis though . . ) on October 7, 2000, at 10:46:02
James,
Interesting and well thoughtout. I do not have a grasp of the technical expertise you display, but I would suggest in simple terms that what you have experienced is the not-so-uncommon build up of tolerance to the medication's effects. Why that happens, I think you understand better than I.I do know of a couple medications however that can do much the same thing as stimulants, except without the tolerance buildup. Unfortunately your doctor won't know about them or be able to prescribe them. That's because they are widely used throughout the world, but not in the USA. The two medications are Amisulpride and Adrafinil.
Amisulpride blocks presynaptic D2 receptors at low doses and stimulates dopamine function. Except over time there is no tolerance buildup, usually (not always). But usually. Adrafinil is an alpha-1 agonist. There is some debate at this board as to whether that's actually what it is or not, but all literature including the manufacturer's insert says it is.
These two meds I discovered after years and years of being disappointed with dozens of other meds my doctors tried on me. I have tried Ritalin, Adderall, and Modafinil, so I do have some experience to compare. Either Amisulpride or Adrafinil can work to:
-Cure depression, especially the apathetic anhedonic blah type
-Increase vigilance and interest in life
-Increase motivation
-Increase focus and concentration
-Increase mental functionIn my own experience with these meds, they are outstanding for treating depression and ADD or ADHD symtoms or any combination of them. How or why I don't know. I just know they work. I've discovered over time that often our best thoughtout explanations and theories don't pan out in reality anyway, so I go by results instead.
It's a totally different arena, ordering your own medications from abroad, and not having to see a doctor. It takes some getting used to. And it's definately not an option for someone who doesn't know what they're doing. But you sound like you are well aware of things. That's why I mention these options to you.
John
poster:JohnL
thread:45914
URL: http://www.dr-bob.org/babble/20000926/msgs/46044.html