Posted by James (I do a mean Elvis though . . ) on October 7, 2000, at 10:46:02
Yo!,
I'm not sure where to start, it seems I've struggled with this problem for quite some time.
I was diagnosed with ADD about 8 months ago, and prescribed Adderall to mitigate the symptoms, which it did beautifully and heartily at first, but over time became nearly useless as a pharmacological agent. Indeed, the depression and lethargy induced by only half of my initial dose has led to my abstinence.
However, the medicine changed my life so greatly, and, until now as I may be switching doctors, my doctor decided against Ritalin when the Adderall lost its efficacy. With my comparitevely elementary psychiatric insight, as much as I can, I disagree with this, as it has been thought (what in science is known beyond doubt?) that Ritalin and Adderall act through different pharmacological mechanisms, viz., methylphenidate on vesicle NT, and Amphetamine on Cytoplasmic NT.
So, do make a long story short and painful, I ventured out on my own to rectify whatever caused the Adderall to fail, though I had no idea what it was, and still don't- though I have many ideas.
My first step, after learning the basics, was the most obvious assuming Taxyphyliasis(sp?) as the culprit, viz., I procured an Anti-Parkinsonian agent (L-DOPA with a peripheral decarboxylase inhibitor), in an attempt to replase depleted NT. This worked briefly, however, soon thereafter I experienced the most potent depression, lethargy, and slowness of movement commonly ascribed to psychostimulant overdose, or at least a dosage to strong. After consideration, I believe that this depression or general placidness follow exactly the symptomology of Parkinson's Disease. Therefore, I now seek to show, as I am not sure of my idea's validity, that the Parkinson's-like symptoms of stimulant excess are caused by Striatal inhibition of DA transmitter, via the post-synaptic DA autoreceptors.
I will study this, in one of my more foolish ventures, with DS-121: a DA autoreceptor antagonist. It is my hope that the de-inhibition of striatal DA transmitter will restore the efficacy of the mixed Amphetamine salts combined with the L-DOPA. Somehow, I believe with due reservation, I've come to know the difference between cortial and striatal stimulation, as I usually have some sort of hyper-mild headache in absence of cortical stimulation.
I have many more ideas other than these, and not only limited to Adderall, which are in part listed on my website: http://eccentrix.com/misc/madscientist.
However, my question is thus: Are my efforts merely reliving the progression of someone's past folly, that is, has someone already attempted what I am about to attempt with failure. I can hardly think so, since DS-121 is a new agent. I can supply a technical sheet to someone if they desire and are interested in this agent. (myfriendharvey2@hotmail.com)
I would appreciate any opinions on my endeavours: something I overlooked or am ignorant of, just in case.
Thanks!
Rock On,
-James
P.S.- I know I'm not a doctor, etc., etc., but mine is an act of desperation, not an act of carefully weighed consequence.
poster:James (I do a mean Elvis though . . )
thread:45914
URL: http://www.dr-bob.org/babble/20000926/msgs/45914.html