Posted by SLS on October 7, 2000, at 21:40:42
In reply to Re: ketamine drops ------ SLS, Andrew B, Anita, posted by shellie on October 5, 2000, at 23:27:48
Thanks Shellie.
This sort of study reminds me of procaine challenges performed at the NIMH. It is not so much that procaine was being considered as a clinical antidepressant, but rather, that it served as a biological probe to help illucidate the neurochemistry of affective disorders.
- Scott
> ...but I did find the article on medline:
>
> TITLE: Antidepressant effects of ketamine in depressed patients.
> AUTHORS:
> Berman RM; Cappiello A; Anand A; Oren DA; Heninger GR; Charney DS; Krystal JH
> AUTHOR AFFILIATION:
> Abraham Ribicoff Center Clinical Neuroscience Research Unit of the Connecticut Mental Health Center, New Haven 06519, USA.
> SOURCE: Biol Psychiatry 2000 Feb 15;47(4):351-4
> CITATION IDS: PMID: 10686270 UI: 20153964
> ABSTRACT:
> BACKGROUND: A growing body of preclinical research suggests that brain glutamate systems may be involved in the
> pathophysiology of major depression and the mechanism of action of antidepressants. This is the first
> placebo-controlled, double-blinded trial to assess the treatment effects of a single dose of an N-methyl-D-aspartate
> (NMDA) receptor antagonist in patients with depression. METHODS: Seven subjects with major depression completed 2
> test days that involved intravenous treatment with ketamine hydrochloride (.5 mg/kg) or saline solutions under randomized, double-blind conditions. RESULTS: Subjects with depression evidenced significant improvement in
> depressive symptoms within 72 hours after ketamine but not placebo infusion (i.e., mean 25-item Hamilton Depression Rating Scale scores decreased by 14 +/- SD 10 points vs. 0 +/- 12 points, treatment).
> CONCLUSIONS: These results suggest a potential role for NMDA receptor-modulating drugs in the treatment of depression.
>
> Hope you feel better soon,
>
> shellie
> p.s., do we need a team uniform?
poster:SLS
thread:45801
URL: http://www.dr-bob.org/babble/20000926/msgs/45935.html