Posted by SLS on October 5, 2000, at 8:56:22
In reply to ketamine drops ------ AndrewB, SLS, posted by shellie on October 4, 2000, at 21:53:45
Dear Shellie,
> Also, is something else becoming wrong with my brain that I am even thinking about neurotransmitters?Shellie, can you be more specific about your concerns here?
> Andrew, I did read one small (N=7) ketamine study on medline and read what Dr. Goldstein had to say about it.What was the title of the study you found on Medline? I'd like to take a look at it.
> But explain to me why I might have an interest in it.
> Ketamine (apparently?) increases dopamine.
> So based on the above, maybe my body just doesn't want any more dopamine stimulated.I am afraid to draw any conclusions as to what exactly ketamine does that might help with depression. It does so many things. One thing I read indicates that the increase in dopamine release provoked by initial dosing of ketamine is attenuated with continued dosing. Ketamine has in common with PCP (angel's dust?) the ability to block NMDA receptors. Ketamine is sometimes used experimentally to produce schizophrenic, psychotic, and dissociative symptoms in healthy human volunteers for study. Does Dr. Goldstein mention this? Ketamine is used frequently as a recreational drug and has significant abuse potential.
I would like to see a study of the use of ketamine in depressive illness that is conducted for a period longer than 72 hours.
> 1. adderall, ritalin, and dexadrine all increase dopamine and all have bad effects on me.Sedation?
> 2. codeine reduces dopamine and has a great effect on me.
Can you describe in what ways codeine makes you feel better? How long does this improvement last for? Can you extend the improvement by taking subsequent dosages, or does the effect disappear regardless of further dosing?
Naltrexone produces sedation in you, right? Do you feel activated when you take codeine?
> Where has my logic gone awry here?
It hasn't.
> Or am I making this too simplistic?
Yes, as are we all.
> What happened to the person who went to a new pdoc and was relieved to put it in his hands?
> (It was only last week!)Who?
- Scott
poster:SLS
thread:45801
URL: http://www.dr-bob.org/babble/20000926/msgs/45811.html