Posted by stephanie l. on September 30, 2000, at 15:01:37
In reply to Re: Stopping and Restarting MAOI----SLS, posted by SLS on September 30, 2000, at 13:04:50
> Dear Stephanie,
>
> If the only thing that stands in the way of your trying reboxetine is that you have no source, I can provide information as to a reputable and reasonably priced pharmacy in London, England. If your doctor is willing to use it right now knowing that you are obtaining it from a foreign source, please email me. I had a bad reaction with reboxetine. It made my depression worse, produced anxiety, and provoked thoughts of suicide. This, of course, is a risk of all antidepressants, so I would make a decision based on just one account. But it can happen. I know of two other people for whom reboxetine exacerbated their depression. However, it seems that reboxetine, a SNRI (selective norepinephrine reuptake inhibitor), may be generally more effective than the SSRIs (selective serotonin reuptake inhibitor). I would DEFINITELY try it if I were you. Both yohimbine and reboxetine work on norepinephrine. That yohimbine helps you may be a good indication that reboxetine will hit the target and chase away the beast.
>
> Now for the tricky stuff. It is my speculative opinion that it is most likely safe to combine reboxetine with the Nardil you are currently taking. If I had not had such a bad reaction to reboxetine, my doctor was prepared to add Nardil. Yohimbine is another story. I would urge you to discontinue yohimbine before you begin reboxetine. There is no two-week "wash-out" period, so you can probably begin reboxetine a few days after your last dose of yohimbine. You can try to add it back later if you feel you need it. I know that Vivactil is a potent norepinephrine reuptake inhibitor, but reboxetine is different enough that I would not guarantee that it will mix as safely with yohimbine as does Vivactil. It is most likely that you did not tolerate "normal" dosages of yohimbine PRECISELY because it was potentiated (exaggerated) by Vivactil.
>
> Have you ever tried desipramine (Norpramin)? Desipramine is definitely a SNRI.
>
>
> - Scott
Dear Scott:Thanks for all the great information, especially on quitting yohimbe before I start reboxetine.
I do have some reboxetine, which I got overseas; the only thing that is stopping me from taking it is my doctor. I know he wouldn't like it because it is not yet approved in the US. I can't afford to lose him as my doc. I saw 7 other docs (including the so-called "best" pharmacologists in town) before I found him.
I am sure he is the only doc here who has the experience and willingness to prescribe the kind of combination of meds I am on. It took us 3 years of trying l5 medications (not counting the various combinations of those meds) to find something that worked reasonably well.
I know reboxetine might not work. My experience is that meds that tend to be stimulating are the ones that might work for me.
The SSRIs did nothing. I am also open to trying some of the meds I see mentioned in this board, like amineptine, apomorphine, and amisupride.
You asked about desipramine; I tried it for several weeks and it put me to sleep for l8 hours a day. I was already on Nardil and Wellbutrin when I tried it, and I don't know if that had any effect or not. So... how are you doing on your trial?
Stephanie
poster:stephanie l.
thread:43904
URL: http://www.dr-bob.org/babble/20000926/msgs/45533.html