Posted by SLS on August 26, 2000, at 11:42:23
In reply to Re: Reboxetine/SSRI combos/SUNNELY, posted by Sunnely on August 25, 2000, at 19:58:27
> Reboxetine (Edronax, Vestra) and desipramine (Norpramin) both act as norepinephrine reuptake inhibitor. Reboxetine is "cleaner" than desipramine, however. Desipramine, apart from inhibiting norepinephrine uptake, carries the extra baggage of blocking the muscarinic cholinergic receptors and alpha1-adrenergic receptors, which can result in unwanted side effects (e.g., blurred vision and drop in blood pressure, respectively).
Hi Sunnely.Your command of pharmacology continues to astound me.
I didn't know that desipramine blocked NE alpha-1 receptors. It seems to me that this might explain its purported effect to mitigate MAOI-tyramine pressor reactions. Are the other tricyclics similarly antagonistic to NE alpha-1 receptors?
- Scott
poster:SLS
thread:43574
URL: http://www.dr-bob.org/babble/20000822/msgs/43776.html