Posted by Sunnely on August 25, 2000, at 20:45:20
In reply to Re: Reboxetine/SSRI combos/SUNNELY, posted by Anna P. on August 25, 2000, at 0:49:15
> > > Thank you Sunnely,
>
> These are valuable info for me. I had big hopes for combining Serzone and Reboxetine. Now I'm concerned. How about Remeron?
> I have a treatment resistant depression.
>
> AnnaI assume you meant Remeron (mirtazapine) and reboxetine in combination. Probably good augmenters to each other especially in treatment-resistant depression.
No significant pharmacokinetic drug-drug interactions involved with this combination. Mirtazapine is metabolized by CYP1A2, CYP2D6, and CYP3A4. In turn, it is a weak inhibitor of these liver enzymes (CYPs). As I have mentioned in my previous response, reboxetine is primarily metabolized by CYP3A4 therefore, expect no appreciable increase in reboxetine blood level when combined with Remeron.
Like Remeron, reboxetine does not interfere with the action of the cytochrome enzymes (CYPs), therefore expect no appreciable increase in Remeron blood level with this combination. Also, doubt any serious pharmacodynamic drug-drug interaction involved with this combination.
JMHO (Just my humble opinion).
poster:Sunnely
thread:43574
URL: http://www.dr-bob.org/babble/20000822/msgs/43726.html