Posted by SLS on July 30, 2000, at 15:48:30
In reply to Why does SAMe make me so fatigued? » shellie, posted by Julie Ann on July 30, 2000, at 11:00:38
Hi Julie Ann
> I take Wellbutrin SR 300mg, Effexor SR 300mg, Neurontin 1800, and Melatonin and Trazadone for sleep at night.
> My diagnosis is Severe Major Chronic Depression. I don't feel depressed due to the effects of all the medication I take. My main problem is that I am tired a lot, and I sleep 12 hours per day.
It is possible that the SAMe is increasing the production of endogenous (by the body) melatonin and serotonin. Perhaps this extra melatonin is working additively with that which you are taking as a supplement and thus producing more sleepiness. It is possible that the extra serotinin is working to potentiate the effects of either the trazodone or the Effexor.
If you are so sleepy, why do you take trazodone and melatonin? Perhaps it is time to cut back on the trazodone. Anything more than 75mg at night may be causing sluggishness early the next day.
If SAMe isn't helping you in any way, I guess discontinuing it would help. I suspect that you may be taking too much trazodone.
Good luck.
- Scott
poster:SLS
thread:41637
URL: http://www.dr-bob.org/babble/20000729/msgs/41767.html