Posted by SLS on June 29, 2000, at 10:59:03
In reply to Re: sulpiride/Michael, posted by Johnturner77 on June 29, 2000, at 8:56:54
> > > I´m taking sulpiride with excellent results, but I´ve read it could induce extrapyramidal symptons in 30% of uusers, even parkinsonism and tardive diskinesia, as other neuroleptics. Is that true? Is amisulpride better in this sense? Can anybody help me?
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> I don't believe extrapyramidal effects are an issue at AD doses. I am not as familiar with Sulpride, but Amisulpride is a neuroleptic at high doses and an AD at low doses. This is because it preferentially blocks dopamine at presynaptic sites. So at low doses it actually increases dopaminergic activity. I beleve Sulpride acts in a similar way. Therefore, at low doses, it might actually work to prevent extrapyramidal symptoms. I hope someone will correct me if this isn't correct.
Sulpiride is indeed similar to amisulpride, both in stucture and function in the ways you describe. I don't think either of these drugs can help prevent EPS, but it is hoped that they are not as likely to produce them at the low dosages used for depression. I’ll keep an eye out for more concrete evidence that this is the case. Sulpiride does cause EPS, including tardive dyskinesia. I am not sure that it is significantly safer in this regard than the older neuroleptics. Some of the studies I have seen indicate that it may not be. By contrast, the newer “atypical” neuroleptics, which include Zyprexa, Risperdal, Seroquel, and Clozaril, are less likely to cause EPS and can even help minimize those that are produced by the other classes of neuroleptics.Since I am taking sulpiride, I too would like to compare the rates of occurrence of EPS between it and amisulpride. There’s a mess of literature to look at and interpret. I think studies of newer drugs tend to be more lenient when evaluating their potential to produce adverse effects.
Please pass the salt.
- Scott
poster:SLS
thread:31704
URL: http://www.dr-bob.org/babble/20000619/msgs/38701.html