Posted by SLS on June 26, 2000, at 8:14:33
In reply to Re: adrafinil - SLS, posted by JohnL on June 26, 2000, at 4:09:32
The following is an excerpt from a recent Cephalon package insert for Provigil (modafinil). The insert is copyrighted 1999. It details the reasons why it has been concluded that Provigil does NOT bind to and stimulate NE alpha-1 receptors.
"Modafinil does not appear to be a direct or indirect alpha-1 adrenergic agonist. Although modafinil-induced wakefulness can be attenuated by the alpha-1 adrenergic receptor antagonist, prazosin, in assay systems known to be responosive to alpha-adrenergic agonists, modafinil has no activity. Modafinil does not display sympathomimetic activity in the rat vas deferens preparations (agonist-stimulated or electrically stimulated) nor does it increase formation of the adrenergic-mediated second messenger phosphatidyl inositol in in vitro models. Unlike sympathomimetic agents, modafinil does not reduce cataplexy in narcoleptic canines and has minimal effects on cardiovascular and hemodynamic parameters."
I don't know if this information applies to adrafinil. My guess is that it most likely does.
- Scott
poster:SLS
thread:37844
URL: http://www.dr-bob.org/babble/20000619/msgs/38359.html