Posted by JohnL on June 25, 2000, at 5:55:00
In reply to Re: adrafinil, posted by SLS on June 24, 2000, at 15:36:47
>
> > It, like provigil, is thought to work via stimulation of the alpha-1 receptors - which are the receptors norepinephrine stimulates.
> >
> > However, they're not exactly sure of the precise mechanism or method of action for either (I believe all of the above is accurate - someon please correct me if I'm mistaken, or add if I've left stuff out)
>
>
> I get the impression that the increased levels of extracellular glutamate produced by Provigil may play a greater role in its effects on mood and wakefulness than does alpha-1 agonism. Most of the newer stuff I see on Medline indicates that alpha-1 receptor pathways must be intact to facilitate the effects of Provigil, but are not necessarily affected directly by it.
>
> I'd like to see the original studies that determined the "putative" binding of Provigil to NE alpha-1 receptors. Can anyone provide references? From what I can see, it may not do so at all. The package insert declines to include it as a possible mechanism of action.
>
> I doubt Provigil is an alpha-1 agonist as it does not prevent or mitigate cateplexy in narcolepsy.
>
>
> - ScottScott,
You may be onto something here. I used to try amino acid supplements. At one time I focused on glutamate chemistry. I got much worse. I also got worse with Provigil. Coincidence or connection?All I know for sure is that I have tried both Provigil and Adrafinil and they are not at all similar.
poster:JohnL
thread:37844
URL: http://www.dr-bob.org/babble/20000619/msgs/38316.html