Posted by Rick on June 11, 2000, at 17:02:22
In reply to Re: More:Provigil poop out;klono counteracts provigil?, posted by Rick on June 11, 2000, at 16:49:29
(As anticipated, my response to Scott was cut off midway. Continuing...)
"The exact mechanism of action is unclear, it does not appear to alter the release of dopamine or norepinephrine, it may exert its stimulant effects by decreasing GABA-mediated neurotransmission, although this theory has not yet been fully evaluated; several studies also suggest that an intact central alpha-adrenergic system is required for modafinil's activity; the drug increases high-frequency alpha waves while decreasing both delta and theta wave activity, and these effects are consistent with generalized increases in mental alertness."
Finally, I just ran across an interesting new Medline abstract of a small study of Provigil augmentation of antidepressants. I'll post that separately.
Rick
> What are the current thoughts regarding the role of NE alpha-1 agonism in the wakefulness-promoting properties of Provigil?
>
> > -- While similar in many ways, different benzos vary in strength and theraputic value. For instance, Klonopin is a high-potency benzo that has been proven very effective in Social Phobia, while Valium usually has no value at all in treating this form of anxiety. Moreover, Klonopin's unique effects in a variety of non-anxiety disorders such as epilepsy, restless leg syndrome, dystonia, and tremor, suggestions a pharmacology which may involve more than simple GABA agonism.
>
> As far as the varied effects of the benzodiazepines are concerned, one factor underlying them may be that there are different subtypes of benzo-receptors to which they bind with varying affinities. In addition, I recall that Klonopin (clonazepam) was thought to have serotonergic properties.
>
> > --If I was reading the studies correctly, the observed GABA-reduction with Provigil (and again, occuring only in selected site/dosage situations) maxed at 20%. (It was hard for me to understand the data as presented. I *believe* the 80% figure cited represented the amount of GABA *maintained* at those
poster:Rick
thread:36517
URL: http://www.dr-bob.org/babble/20000610/msgs/36947.html