Posted by Rick on June 10, 2000, at 16:32:05
In reply to Re: Provigil poop out; klonopin counteracts provigil?, posted by Rick on June 10, 2000, at 16:20:28
(I'm still having trouble getting everything to post at once, so here's more -- hopefully through the end):
-- For me, concurrent use of three CYP 450-metabolized drugs might be increasing the bioavailabily and clinical effect of some of them. A likely candidate this kind of potentiating effect would be the Klonopin, which would help offset any anti-GABA effects of Provigil. From everything I've read, Provigil shows little increase in benefit at dosages higher than the standard 200mg; while proportionally, bioavailabilty increases add to Klonopin's anxiolytic properties over a pretty wide range. Also, while not specifically tested, phrmacologists seem to widely believe that Serzone inhibits metabolism of Klonopin, and thus increases its blood levels. It has been demonstrated that Serzone doubles Xanax availability two-fold, and increases blood concentration of another benzo (was it triazolam?) so dramatically that concommitant (sp?) use is discouraged. Incidentally, the official Provigil monograph specifically cites studies that looked at its use with selected benzos, and does not report any watchouts for such a cobination While their focus was on safety of the combination (no problems found), I would suspect that loss of anxiolytic effect would have been led to a warning, contraindication, or suggestion to monitor benzo effectiveness and increase the benzo dosage if warranted. Finally, while new interactions are being uncovered for lots of psychoactive drugs every year (some of them beneficial), drug interaction sites such as Mayo Clinic, Drug Data Bank, and CVS show very few reported interactions with Provigil, and in particular none between Provigil and any benzo. While Provigil has only been in the U.S. about 18 months, France -- a country with heavy benzo usage -- has had over ten years to uncover interactions. (It would be interesting to see a French monograph for Provigil.)
-- To me, this is probably the best evidence of all that Provigil doesn't kill the ef
poster:Rick
thread:36517
URL: http://www.dr-bob.org/babble/20000610/msgs/36858.html