Posted by SLS on May 17, 2000, at 8:32:24
In reply to Re: Amineptine substitute?, posted by PeterJ on May 16, 2000, at 18:58:50
Dear Peter,
I want to thank you for your concern and your detailed contribution here. I find it very relevant personally, as I will probably be exploring dopaminergic drugs in my treatment.
> Initial enhancement by many substances of
dopamine activity often results in only short-
lived benefits. Dr. Baron Shopsin, who
studied several dopamine drugs clinically in the
70s and 80s found this to be their achilles heel.
Dr. Shopsin was my doctor for a few years. I briefly served as one of his research assistants. He was one of Nathan Klein's protoges. He was brilliant. Unfortunately, he left town.He liked to use pemoline to augment other drugs, particularly Parnate.
Cocaine induces an increase in the release of dopamine in the nucleus accumbens. I am not sure as to how this occurs, but I have not yet seen an explanation that involves a action at the synapse. I guess it is more the result of its DA reuptake inhibition in afferent pathways.
- Scott
poster:SLS
thread:33419
URL: http://www.dr-bob.org/babble/20000517/msgs/33756.html