Posted by Sherry on May 9, 2000, at 17:56:22
In reply to Re: Parnate + amisulpride, Provigil, Mirapex..., posted by SLS on May 9, 2000, at 7:08:41
Hey Scott,
I don't know much about your depression, but I am wondering if you have looked into physical causes of your depression? I have been researching cushing's syndrome, and I have pretty much all the symptoms. Plus, I don't respond to any AD's. However, unlike you, I can't tolerate them even at low doses. I go Thursday to begin being tested for it. I have been to many doctors and no one even thought of it. I did the research myself, and my doctor scratched his head, looked puzzled, and said, "it's a definite possibility." I don't know, but we'll see. Just a thought. ~Sherry
> Hey guys.
>
> Much thanks for your replies.
>
>
> Scott:
> > > I am particularly interested to receive some feedback regarding the following combinations:
> > >
> > > 1. Parnate + amisulpride or sulpiride
> > >
> > > 2. Parnate + Provigil (modafinil) or adrafinil
> > >
> > > 3. Parnate + mazindol (Mazinor)
> > >
> > > 4. Parnate + amineptine
> > >
> > > 5. Parnate + Adderal or Desoxyn
> > >
> > > 6. Parnate + pramepexole (Mirapex)
>
>
> AndrewB:
> > There was a post about a month or so ago that you may want to search back for that talked of someone's experience combining a stimulant with an MAOI, Parnate I think. an excessive rise in blood pressure was a concern, so when the stimulant was first added, the doctor watched the blood pressure for awhile in his office.
>
> I think that was me.
>
>
> JohnL:
> > Though we don't hear too much of these combinations today, they weren't uncommon in the older days. MAOIs + dopamine drugs or norepinephrine drugs don't have nearly the danger of combinations with serotonin drugs. I would think all the combinations you mentioned are quite possible candidates.
>
>
> I've tried the following:
>
> - Parnate 60mg + desipramine + Ritalin
>
> - Parnate 120mg + desipramine + Lamictal
>
> - Parnate 120mg + desipramine + Dexedrine + Synthroid (T4)
>
> - Parnate 120mg + desipramine + bromocryptine (Parlodel)
>
> - Parnate 80mg + imipramine + Lamictal + Depakote
>
>
> Parnate monotherapy produces a mild three-day improvement beginning anywhere between one to two weeks after the first dose. Desipramine and imipramine each produce a moderate to robust three-day improvement beginning on day 13 or 14. Combinations of these can produce a mild improvement in energy that is longer lasting. Both Dexedrine and Parlodel each produce an additional mild improvement for the first three or four-days, and then fades.
>
> I haven't tried Adderal.
>
> > You should rule out Amineptine though. A few suppliers still have it in stock--for a while--but it isn't being marketed anymore and will likely run out at some point. I would hate to get better on a drug only to find out I can't get it refilled down the road.
>
> I know. Sometimes I just want to feel good no matter what.
>
> > Provagil and Mirapex are decent choices too, though they don't have hardly any track record yet for the purposes you mention. In your shoes I would start with just Parnate and see how that goes. It might be all you need. If something else is needed later, then I would look first at the more common things they used to do in the older days. After that I would branch out into uncharted waters. But only after trying more conventional things first. That's just what I would do.
>
> I am very, very interested in the combinations of Parnate with Provigil and/or mazindol (Mazinor). It is my hope that mazindol, an antiobesity drug, may be able to fill a role similar to amineptine. It is a potent dopamine reuptake inhibitor that is often used as a biological probe to assay dopamine transporter. It also inhibits the reuptake of norepinephrine to a degree. I had thought to use it as an adjunct to Parnate and/or amisulpride.
>
> Feel free to continue brainstorming!
>
> :-) Thanks again.
>
>
> - Scott
poster:Sherry
thread:32745
URL: http://www.dr-bob.org/babble/20000508/msgs/32927.html