Posted by SLS on May 9, 2000, at 7:08:41
In reply to Re: Parnate + amisulpride, Provigil, Mirapex..., posted by JohnL on May 9, 2000, at 4:22:51
Hey guys.
Much thanks for your replies.
Scott:
> > I am particularly interested to receive some feedback regarding the following combinations:
> >
> > 1. Parnate + amisulpride or sulpiride
> >
> > 2. Parnate + Provigil (modafinil) or adrafinil
> >
> > 3. Parnate + mazindol (Mazinor)
> >
> > 4. Parnate + amineptine
> >
> > 5. Parnate + Adderal or Desoxyn
> >
> > 6. Parnate + pramepexole (Mirapex)
AndrewB:
> There was a post about a month or so ago that you may want to search back for that talked of someone's experience combining a stimulant with an MAOI, Parnate I think. an excessive rise in blood pressure was a concern, so when the stimulant was first added, the doctor watched the blood pressure for awhile in his office.I think that was me.
JohnL:
> Though we don't hear too much of these combinations today, they weren't uncommon in the older days. MAOIs + dopamine drugs or norepinephrine drugs don't have nearly the danger of combinations with serotonin drugs. I would think all the combinations you mentioned are quite possible candidates.
I've tried the following:- Parnate 60mg + desipramine + Ritalin
- Parnate 120mg + desipramine + Lamictal
- Parnate 120mg + desipramine + Dexedrine + Synthroid (T4)
- Parnate 120mg + desipramine + bromocryptine (Parlodel)
- Parnate 80mg + imipramine + Lamictal + Depakote
Parnate monotherapy produces a mild three-day improvement beginning anywhere between one to two weeks after the first dose. Desipramine and imipramine each produce a moderate to robust three-day improvement beginning on day 13 or 14. Combinations of these can produce a mild improvement in energy that is longer lasting. Both Dexedrine and Parlodel each produce an additional mild improvement for the first three or four-days, and then fades.I haven't tried Adderal.
> You should rule out Amineptine though. A few suppliers still have it in stock--for a while--but it isn't being marketed anymore and will likely run out at some point. I would hate to get better on a drug only to find out I can't get it refilled down the road.
I know. Sometimes I just want to feel good no matter what.
> Provagil and Mirapex are decent choices too, though they don't have hardly any track record yet for the purposes you mention. In your shoes I would start with just Parnate and see how that goes. It might be all you need. If something else is needed later, then I would look first at the more common things they used to do in the older days. After that I would branch out into uncharted waters. But only after trying more conventional things first. That's just what I would do.
I am very, very interested in the combinations of Parnate with Provigil and/or mazindol (Mazinor). It is my hope that mazindol, an antiobesity drug, may be able to fill a role similar to amineptine. It is a potent dopamine reuptake inhibitor that is often used as a biological probe to assay dopamine transporter. It also inhibits the reuptake of norepinephrine to a degree. I had thought to use it as an adjunct to Parnate and/or amisulpride.
Feel free to continue brainstorming!
:-) Thanks again.
- Scott
poster:SLS
thread:32745
URL: http://www.dr-bob.org/babble/20000508/msgs/32868.html