Posted by Rick on April 16, 2000, at 18:13:03
In reply to Brofaromine (Consonar) or toloxatone (Humoryl) ?, posted by Scott L. Schofield on April 16, 2000, at 12:50:46
Awhile back I e-mailed Dr. J.W. Jefferson of Madison, Wisconsin, who performed a study showing brofaromine's efficacy in social phobia (abstract is in Medline). I asked where it was available, having heard that it might be marketed in France. An associate of Dr. Jefferson's wrote back, saying that Dr. Jefferson informed her that brofaromine is no longer available in any country.
It makes no sense that a no-cheese-effect MAOI which has been shown to be more effective than moclobemide would not be marketed, especially when Paxil's advertising and resultant publicity has made social phobia a big potential revenue source. Bringing it back would seem like a win-win for both the manufacturer and patients. Maybe the patent has expired, in which case the manufacturer would have to tweak brofaromine into a "new" drug snag a new patent and make a buck.Rick
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> Has anyone had any experience with either brofaromine (Consonar) or toloxatone (Humoryl) for the treatment of depression?
>
> Brofaromine is considered to be a reversible inhibitor of monoamine oxidase type-A (RIMA), similar to moclobemide (Aurorix, Manerix). It has also been shown to significantly inhibit the reuptake of serotonin. This latter property is thought to contribute to its efficacy in treating both depression and social phobia. It may even inhibit the reuptake of dopamine to some extent.
>
> I wouldn't even know where to get it. I know it is available in Europe. Someone once mentioned Germany, but I think it might also be available in Belgium and possibly Poland, Czechoslovakia, or Brazil.
>
> Toloxatone (Humoryl) is another RIMA that I believe is currently being sold in France. I don't know very much about it
>
> Any input would, as always, be appreciated. Thanks.
>
>
> - Scott
poster:Rick
thread:30218
URL: http://www.dr-bob.org/babble/20000411/msgs/30243.html