Posted by saint james on April 15, 2000, at 16:48:41
In reply to Re: Neurotoxicity - SSRI's may not be so benign..., posted by Sean on April 15, 2000, at 16:21:37
>
> > James here...
> >
> > If you use this logic then humans have been on sertonin agents since the 1950's (imiprimine, TCA's) with no problems.
> >
> > james
>
> james -
>
> i may be totally wrong on this, but i was under
> the impression that the serotonin effects of TCA's
> (except for amitriptyline) was very small in terms of
> ratio to norepinephrine.
James here....Correct, you are wrong. TCA's effect serotonin for the most part, thus accounting for the high rate of sucess. Some do have more of a nor-e effect than others. I know them well as my mood only responds to meds that effect nor-e, but most people need meds that effect 5-HT.
james
poster:saint james
thread:29745
URL: http://www.dr-bob.org/babble/20000411/msgs/30146.html