Posted by Sean on April 14, 2000, at 19:51:39
In reply to Re: Neurotoxicity - SSRI's may not be so benign..., posted by saint james on April 14, 2000, at 19:05:45
> >
> > I've read the entire article (in Brain Research)
> > about the comparative effects of fluoxetine, sertraline,
> > Meridia, Redux, and MDMA on serotonin producing cells.
> >
> > It was found that *all* of these drugs produced a
> > characteristic change in the cells described as
> > "corkscrew shaped" and "swollen axons". What this
> > really means is unkown at the moment, but it doesn't
> > sound very encouraging to me.
> >
>
>
> James here....
>
> I saw this one too, again it was on animals, and in very high doses. All it proves is that animals on high doses of these meds have changes.
>
> jamesjames -
technically you are right, but primates and humans
have been shown (with MDMA at least) to *more* sensitive
than rats with respect to nerve damage. Given that
the rat model of depression and rat-brain synaptosomes
are used to develop antidepressants, I think these
results will eventually be shown to happen in humans.
Mammalian nerve physiology is similar at the functional
level but not the organizational level.Since the substances tested are from different drug
classes, and the only thing that links them is an
effect on serotonin, I think it is important to
find out the mechanism and perhaps fix it. It
would really suck to have the very nerve system I
already have problems with be degraded by therapy...Still takin' my zoloft though... heh heh heh,
Sean.
poster:Sean
thread:29745
URL: http://www.dr-bob.org/babble/20000411/msgs/30039.html