Posted by JohnL on April 6, 2000, at 2:40:51
In reply to Re: JohnL, posted by AndrewB on April 5, 2000, at 13:04:47
> John,
>
> Thank you for another very informative post. Did you experience any depression with Adrafinil or stimulants since both effect NE. By the way how has your trial with stim.s gone?
>
> The reason you did not get depressed with the tricyclics even though they increase NE may lie in their ability to increase serotonin transmission. I did some research and apparently serotonergic agents such as SSRIs are able to inhibit the excitatory response of too much NE. The symptoms of too much NE can include increased heart rate, agitation, anxiety and obsessional thinking including suicidal ideation. I couldn’t find anything that refers to too much NE causing depression. Obviously your experience and Scott’s seems to indicate though that too much NE can indeed cause depression.
>
> AndrewBAndrew,
Actually I did not experience any depression with stimulants or Adrafinil. It's almost as if stimulating NE is a good thing, but merely increasing levels of NE is a bad thing...with me anyway. It's almost as if my NE levels are OK, yet need a kick in the butt.
Nothing so far has had such a positive mood response as Ritalin. But it was so damn abusive for me. I find Adderall much smoother. It provides energy and physical boost, but no mood or mental boost. At this time I am nearing the end of week 1 in trying Adrafinil again. When I used it with Desipramine it was incredible...but also caused incredible impotence. I'm trying it solo now. It does not at all have the good effect as it did with Desipramine, but is friendly to my sex life. I plan on giving it 4 weeks before making any judgements, modifications, or additions. We'll see.
poster:JohnL
thread:28828
URL: http://www.dr-bob.org/babble/20000401/msgs/29051.html