Posted by Scott L. Schofield on March 20, 2000, at 14:20:55
In reply to Re: Mazindol (Mazinor) for depression? Anyone?, posted by saint james on March 19, 2000, at 17:43:21
> > In addition to its initial effect to suppress appetite, mazindol also increases the basal metabolism rate (BMR) to promote thermogenesis. This is accomplished through the activation of brown adipose tissue (BAT) to burn off extra fat. You burn more energy, even while you sit on your butt watching re-runs of the Honeymooners. In addition, mazindol seems to increase (improve) the sensitivity of insulin receptors. The result is a decrease in the release of insulin and a reduction in the amount of glucose withdrawn from the blood stream to be stored as fat. Patients on a reduced-calorie diet who take mazindol lose more weight than those who maintain the same diet but do not take mazindol
> This is true of any diet pill, but long term the amount of weight loss is not significant. The weight loss is greater is the first few weeks, then decreases. How long were the long term studies ?
Why isn't thermogenesis mentioned more often when describing the mechanisms of action of amphetamine? I looked back on Medline to try to find more information about the clinical use of mazindol. The one study I found focusing on the "long-term" use of mazindol did not describe exactly how long they followed their test subjects for. The average amount of sustained weight loss was not substantial, about 7 Kg. I don't know how meaningful this is, since they didn't give any indication as to what the average weight of the subjects were before treatment.
> I am waiting for a diet pill that is specific to weight loss issues w/o being a stim.Had you tried Pondamin or Redux before the sh_t hit the fan? A friend of mine who works for a large brokerage firm described dramatic weight loss in some of her co-workers who had been on fen-phen. They seemed to keep it off. I haven't seen her recently to ask how they are doing, though. Does sibutramine offer comparable results given its actions on NE and 5-HT? I didn't realize how little definitive work has been published in this field. Maybe it's not as rewarding to report failure.
Is there any potential for leptin to be used clinically?
Has growth-hormone ever been used specifically for weight-loss?
The other thing that occurs to me is that a drug like topiramate can cause significant weight-loss. What's going on there?
I'm still hoping to hear from someone who has tried mazindol for depression. There are some published reports citing success. My main interest is to use it in the role of an augmenting agent, similar to the psychostimulants. I'm still trying to find something that would approach nomifensine or amineptine in its ability to inhibit the reuptake of dopamine and/or norepinephrine, and that has demonstrated any antidepressant properties.
- Scott
poster:Scott L. Schofield
thread:27486
URL: http://www.dr-bob.org/babble/20000312/msgs/27657.html