Posted by Scott L. Schofield on March 19, 2000, at 16:20:26
In reply to Re: Mazindol (Mazinor) for depression? Anyone?, posted by AndrewB on March 19, 2000, at 14:33:07
> Scott,
>
> Thanks for the very informative post. Again I learned a lot.
>
> My information says that amineptine is a reuptake blocker of dopamine and has no NE activity. The D2 receptor of the striatum are involved with anxiolytic effects
Hi.
Considering how long amineptine has been around for, there isn't a whole lot of stuff written about it. Most of the literature I came across a while back (too long) always labelled it as being a DA/NE reuptake inhibitor. I notice that the more recent abstracts cited on Medline describe it as being a selective DA reuptake inhibitor.
I couldn't find any study addressing amineptine pharmacology that I would place confidence in. I at least found one that used numbers. It reported that the potency of amineptine to inhibited NE reuptake was about 1/4 of that for DA. My guess is that if it does affect NE, the difference is probably greater than that.
- Scott
>
> AndrewB
poster:Scott L. Schofield
thread:27486
URL: http://www.dr-bob.org/babble/20000312/msgs/27589.html