Posted by Scott L. Schofield on March 10, 2000, at 12:45:34
In reply to Re: Reboxetine vs tomoxetine, posted by Cam W. on March 10, 2000, at 7:35:08
> > > > Would someone please clarify for me what the difference between desipramine and reboxetine is. I know they both effect levels of NE, and that despram. is a tricyclic, but how do they differ chemically? Also, if someone can not take desipramine is it likely that they could not take reboxetine?
> > > Drug companies now develop drugs to bind to as few receptors as possible to minimize side effects. So, you can consider Reboxetine to be like Desipramine, but without as many side effects.> > As Cam mentioned, Desipramine affects multiple sites. But I don't think researchers can fully explain the therapeutic mechanisms of the NE antidepresants, because results vary within that class.
> John is right. It is far more complex than looking at one or two receptors.
I get scared sometimes that drug companies have begun to invest too much into developing drugs that are so specific as to have only one pharmacological action without sufficient grounds to do so. Creating such molecules has great importance in providing tools for elucidating the biology of the human organism in health and disease. However, I'm not sure what criteria are used to decide when to commit the limited resources of a drug company (most importantly, time) into developing such a compound for use as a clinical drug.I really wouldn't mind this sort of thing, were it not to jeopardize my chances of getting well as soon as possible. At the moment, I am all in favor of capitalism. However, I sometimes can't help but to consider the time and money "owned" by a drug company as being part of the collective resources of mankind. I hope the people in a position to make the decisions of how to invest it take this into consideration.
Actually, I'm not sure there is any better way to go about it than the way they do now.
I wonder what ever happened to duloxetine?
- Scott
poster:Scott L. Schofield
thread:26073
URL: http://www.dr-bob.org/babble/20000302/msgs/26628.html