Posted by JohnL on March 10, 2000, at 3:57:04
In reply to Re: Reboxetine vs tomoxetine, posted by sherry on March 9, 2000, at 11:09:35
As Cam mentioned, Desipramine affects multiple sites. But I don't think researchers can fully explain the therapeutic mechanisms of the NE antidepresants, because results vary within that class. For example, someone may do poorly on the primarily NE antidepressants Nortriptyline or Protriptyline, and yet do wonderfully on another primarily NE antidepressant Desipramine. They all have major NE reuptake inhibition, but somehow they actually have other subtle poorly understood differences that probably contribute to therapeutic efficacy. I wish it were as easy as NE reuptake or this or that or whatever, but I think it's a whole lot more complex than that.
poster:JohnL
thread:26073
URL: http://www.dr-bob.org/babble/20000302/msgs/26575.html