Posted by Adam on December 19, 1999, at 12:34:28
In reply to Re: INSOMNIA, posted by Elizabeth on December 19, 1999, at 10:16:22
That's what I was afraid of, melatonin being a derivative of 5-HT. I could find nothing in the
literature about such a combination, though, or melatonin being associated with serotonin syndrome.
Despite the inkling there could be risks, and your apparent confirmation of this, I can't think of a
concrete reason, mechanistically, why this should happen. Do you have any theories. Does melatonin
have sympathomimetic properties? Is it recycled into 5-HT? Is it a 5-HT receptor agonist? Nothing
I have read would indicate any of these possibilites, but that certainly could be because I didn't
know where to look.Thanks in advance for your thoughts...
> > Has anyone tried it? Did it help?
> >
> > Also, has anyone tried this with an MAOI? Are there any risks or issues with dosing beyond whatever should be the normal constraints on its use?
>
> I had mild symptoms of central serotonin syndrome (dilated pupils, inappropriate sweating, and - get this - insomnia) when I tried taking a low dose (1/2 mg I think) with Parnate.
>
> I also tried it when I wasn't taking an MAOI. Despite the fact that I supposedly have a circadian rhythm disorder, it didn't do a thing, even at high doses.
poster:Adam
thread:16735
URL: http://www.dr-bob.org/babble/19991212/msgs/17128.html