Posted by Rick on September 20, 1999, at 3:31:03
In reply to SOCIAL PHOBIA: ANYTHING BETTER THAN NARDIL?, posted by Cynthia on September 10, 1999, at 20:14:29
> HI,
>
> I HAVE TERRIBLE "SOCIAL PHOBIA." MY PSYCHDOC HAS
PRESCRIBED NARDIL AND KLONPIN. BOTH ARE VERY
EFFECTIVE, BUT THE KNOLONPIN MAKES ME DROWSY. THE
PURPOSE FOR USING KLONOPIN AS AN ADJUNCT, I'M
TOLD, IS TO SUPPLEMENT THE NARDIL. THAT IS,
NARDIL, FIRST, AND THEN LOW STEADY STATE DOSE OF
KLONOPIN. MY PROBLEM IS NARDIL HAS CAUSED ME TO
GAIN OVER 20 POUNDS, AND HAS ALSO CAUSED 100%
ANORGASMIA. HAS ANYONE TRIED ANYTHING ELSE THAT
WORKED BETTER THAN NARDIL, WITHOUT THE SIDE
EFFECTS. MY SEARCH OF MEDLINE INDICATES THAT THE
SSRI'S AND THEIR COUSINS GENERALLY ARE NO BETTER
THAN RELIEVING 40-45% OF THE SYMPTOMS, COMPARED
WITH PLACEBO EFFECT OF 20-25%. I DON'T WANT THE
SAME PROBLEMS ASSOCIATED WITH SSRI'S (SEXUAL
DYSFUNCTION), WITH SUCH A LOWER LEVEL OF EFFICACY
COMPARED TO NARDIL. BASICALLY, THEY SEEM TO OFFER
ALL THE NEGATIVES WITHOUT THE BENEFIT, FOR SOCIAL
PHOBIA, THAT IS. I HAVEN'T HEARD ANYTHING ABOUT
REBOXETINE (IN TREATING SP), WHICH IS SOON TO BE
RELEASED IN THE US (4TH QTR 1999). ALSO,
UNDERSTAND GABAPENTIN AND ONDANSETRON DIDN'T MAKE
IT THROUGH STAGE III TRIALS DUE TO LACK OF
EFFICACY.
>
> THERE HAS TO BE SOMETHING! BY THE WAY,
PARNATE'S EFFICACY IN TREATING SP IS EQUIVOCAL.
>
> ANY IDEAS?????????????????--------
Contrary to initial reports, the reversible,
A-selective, and thus "gentle" (no food
restrictions or nasty side effects) MAOI
Moclobemide has recently been shown to be fairly
ineffective for Social Phobia. Yet tests as
recent as 1997 by Ciba-Geigy show Brofaromine,
another reversible, A-selective gentle MAOI to be
VERY effective for SP (e.g., see Medline 1997
study).So why isn't Brofaromide being manufactured
anymore?? At least Moclobemide (Manerix) can be
bought in Canada or mail-ordered to the U.S., but
why wouldn't Ciba withold Brofaromide just as
Social Phobia/Anxiety is finally being recognized
as a HUGELY prevalent mental disorder, and
garnering scads of press...not to mention the
drug's base use as an AD. Is someone asleep at
the wheel and denying the Social Phobics and MAOI
that actually works AND won't make them give up
cheese or sex? What gives? Geez, someone can
make MONEY from this, no??
poster:Rick
thread:11383
URL: http://www.dr-bob.org/babble/19990914/msgs/11799.html