Posted by JohnL on September 17, 1999, at 16:37:50
In reply to Selegiline/Moclobemide-Same??, posted by Bones on September 17, 1999, at 6:14:42
Hi Bones. I remember the posts of Selegiline and Klonopin, but that wasn't me. Sounds like an intriquing combo though. I've never tried a benzo. But, answers to your questions.
1) Selegiline and Moclobemide are both MAOIs, but not at all the same. Selegiline in high doses, perhaps over 20mg and on up, might act more like Moclobemide, but still they are not really similar.
2) I don't know if Selegiline is available in Canada, but it is easily available on the net with quick delivery and no prescription.
3) & 4) Moclobemide and SSRIs or TCAs can be combined. The Canadian doc I spoke with does it. He uses Moclobemide as the primary treatment with small doses of any other AD as an add-on. Small doses I think is the important issue to keep the combo safe. He always starts the Moclobemide first, adding something else on later if needed, but NEVER the other way around. Not sure why, but he must have a good reason.Generally speaking, Moclobemide has a good reputation as far as side effects goes, but its efficacy is in question. Clinical studies indicating its weakness were done at medium doses. It apparently is very effective at its maximum dose and even higher, with supposedly very favorable side effects compared to SSRIs, according to excerpts of patients and doctors that have used it. I guess the same applies to Selegiline. From what I have read, a high dose is needed. Bottom line though, who knows, we all respond so differently.
poster:JohnL
thread:11691
URL: http://www.dr-bob.org/babble/19990914/msgs/11715.html