Posted by Mike on September 17, 1999, at 13:22:18
In reply to Selegiline/Moclobemide-Same??, posted by Bones on September 17, 1999, at 6:14:42
> Hi Folks:
>
> As you can see I resume my search for the perfect med. I was off meds. for about three weeks. Life is too difficult without them. The "can't live with em" ... "can't live without em" predicament.
>
> Anyway, a couple of questions for anyone who can answer. In a post about a month or so ago, JohnL mentioned his cocktail for Social Phobia ... Selegiline/Klonopin/Pindolol. I'm investigating this combo right now. Perhaps substituting a sedative tricyclic at night for the klonopin (still cautious about introducing a benzo into my regiment).
>
> My questions are:
>
> 1) Are selegeline & manerix (moclobemide) the same kind of drug?
> 2) Can selegeline be prescribed in Canada??
> 3) Can Moclobemide / Tricyclics be combined together?
> 4) Can Moclobemide / SSRI's be combined together?
>
> Phew!! I know there's a lot there.
>
> It looks like it's going to be a lovely September day in Toronto. Floyd is nowhere in sight!!
>
> Take good care my cyberfriends!Hi,
Regarding your questions:
(1) My understanding is that selegiline (Deprenyl) and Moclobemide are not similar. Selegiline is typically prescribed at doses less than 10-15 mg/day to maintain its MAO-B inhibiting activity. This avoids the dietary restrictions associated with the non-selective MAOI's. Moclobemide, I understand is a reversible inhibitor of MAO-A. Your psychopharmacologist may be able to prescribe both Moclobemide and Deprenyl to you as a way to "fine-tune" the MAO-B inhibiting activity. However, I believe he would have to be careful to keep your Deprenyl under the 10-15mg/day limit to avoid MAO-A activity.
(2) As far as combining Moclobemide with SSRI's, I would think not, as both affect Serotonin levels and there could be a risk of Serotonin syndrome.
(3) The longer-acting benzodiazepines, such as Klonopin, are typically better tolerated than the shorter-acting benzo's, such as Xanax. Also, the benzodiazepines are not the "tranquilizers" of the past, such as valium. Klonopin, for example, on a maintenance dose of 2.0mg/day is not particularly sedating, but is quite effective in controlling panic and social phobia. You can augment your maintenance regimen with an addition 0.5 to 1.5 mg prior to a major event, such as public speaking, several hours beforehand.As always, please be sure you are obtaining your prescriptions and information from a personal consultation with an experienced psychopharmacologist. Most university-based anxiety disorder clinics have this level of experience and knowledge.
poster:Mike
thread:11691
URL: http://www.dr-bob.org/babble/19990914/msgs/11706.html