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Dr. Bob is Robert Hsiung, MD,
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Posted by linkadge on January 9, 2015, at 20:39:49
http://www.medicalnewstoday.com/releases/287733.php
The study seems to suggest that sigma-1 agonists can prevent the NMDA hypofunction that occurs with cb-1 agonism.
In other words, in cases where there is excessive cannabinoid signalling (causing glutamate hypofunction) sigma-1 agonism can reverse / offset this.
This possibly explains some of the effect of fluvoxamine on psychotic depression.
Linkadge
Posted by SLS on January 9, 2015, at 21:40:14
In reply to Sigma-1 Cannabinoid Interaction - Study, posted by linkadge on January 9, 2015, at 20:39:49
> http://www.medicalnewstoday.com/releases/287733.php
>
> The study seems to suggest that sigma-1 agonists can prevent the NMDA hypofunction that occurs with cb-1 agonism.
>
> In other words, in cases where there is excessive cannabinoid signalling (causing glutamate hypofunction) sigma-1 agonism can reverse / offset this.
>
> This possibly explains some of the effect of fluvoxamine on psychotic depression.
>
> Linkadge
Nice work.
- Scott
Posted by Phillipa on January 10, 2015, at 9:20:04
In reply to Re: Sigma-1 Cannabinoid Interaction - Study » linkadge, posted by SLS on January 9, 2015, at 21:40:14
So does this mean I can smoke marijuana and not become psychotic? And if get Alzheimers marijuana is a drug that will be used. I'm serious as don't understand all the studies. Phillipa
Posted by linkadge on January 10, 2015, at 19:21:43
In reply to Re: Sigma-1 Cannabinoid Interaction - Study, posted by Phillipa on January 10, 2015, at 9:20:04
Basically, it suggests that sigma agonists like fluvoxamine might block the ability of cannabis to cause psychotic states.
Posted by Phillipa on January 10, 2015, at 19:28:38
In reply to Re: Sigma-1 Cannabinoid Interaction - Study, posted by linkadge on January 10, 2015, at 19:21:43
Link thanks since no marijuana it doesn't apply to me. Phillipa
This is the end of the thread.
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