Psycho-Babble Medication Thread 95607

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Toxic Serotonin Syndrome or narcotic reaction?

Posted by Po_thang on February 26, 2002, at 15:51:38

My Doc tapered my meds Serzone, Elavil and Ativan for 3 days then started Celexa and Xanax. I had been on those meds for four years. On the second day of Celexa (I also have neuropothy pain) took an oxycodone and had uncontrollable shaking within 10 mins. and ended up in ER, dilated pupils, could not talk, could not make legs move was released after 6 hours. Now off all meds cold turkey except Ativan. Did I have Toxic Serotonin Syndrome or bad reaction to oxycodone? I'm not getting an answer from my Doc. I'm very sensitive to meds and Serzone is the only one I had never reacted too. Even the Elavil caused insomnia. Any advice? I am also having anti-depressant withdrawals, how long is this going to last?

 

Re: Toxic Serotonin Syndrome or narcotic reaction? » Po_thang

Posted by Ritch on February 27, 2002, at 0:45:10

In reply to Toxic Serotonin Syndrome or narcotic reaction?, posted by Po_thang on February 26, 2002, at 15:51:38

> My Doc tapered my meds Serzone, Elavil and Ativan for 3 days then started Celexa and Xanax. I had been on those meds for four years. On the second day of Celexa (I also have neuropothy pain) took an oxycodone and had uncontrollable shaking within 10 mins. and ended up in ER, dilated pupils, could not talk, could not make legs move was released after 6 hours. Now off all meds cold turkey except Ativan. Did I have Toxic Serotonin Syndrome or bad reaction to oxycodone? I'm not getting an answer from my Doc. I'm very sensitive to meds and Serzone is the only one I had never reacted too. Even the Elavil caused insomnia. Any advice? I am also having anti-depressant withdrawals, how long is this going to last?

Hi,

If you had only tapered tricyclic antidepressants (the Elavil) for "three days"-you probably hadn't gotten rid of too much of it (sometimes takes 2-3 weeks to wash out well). I was on doxepin (Sinequan) back in the early 80's and had a bad cold and was given some codeine cough syrup. Well, I went to work and got very dizzy and almost passed out after a single recommended dose of the codeine (orthostatic hypotension-low blood pressure-high heartrate).

Celexa may have been what added to it as well. If you had all of those negative reactions to other antidepressants you could be bipolar. If so, it doesn't surprise me you had a run-in with the switchover to Celexa (you didn't mention the dosage). The first time I tried an SSRI (Prozac)-I started off with a full 20mg capsule every morning. Well...within about 10-days I had dilated pupils, sweating, insomnia, and mild nighttime hallucinations, had to drop the dose back quite drastically-and then I was Ok. But, I am bipolar and in retrospect that doesn't surprise me considering all of the sensitivity reactions I have had with a lot of antidepressants. You just may need much reduced dosages and you will be OK.

Mitch

 

Re: Toxic Serotonin Syndrome or narcotic reaction? » Ritch

Posted by Po_thang on February 27, 2002, at 1:37:13

In reply to Re: Toxic Serotonin Syndrome or narcotic reaction? » Po_thang, posted by Ritch on February 27, 2002, at 0:45:10

> > My Doc tapered my meds Serzone, Elavil and Ativan for 3 days then started Celexa and Xanax. I had been on those meds for four years. On the second day of Celexa (I also have neuropothy pain) took an oxycodone and had uncontrollable shaking within 10 mins. and ended up in ER, dilated pupils, could not talk, could not make legs move was released after 6 hours. Now off all meds cold turkey except Ativan. Did I have Toxic Serotonin Syndrome or bad reaction to oxycodone? I'm not getting an answer from my Doc. I'm very sensitive to meds and Serzone is the only one I had never reacted too. Even the Elavil caused insomnia. Any advice? I am also having anti-depressant withdrawals, how long is this going to last?
>
> Hi,
>
> If you had only tapered tricyclic antidepressants (the Elavil) for "three days"-you probably hadn't gotten rid of too much of it (sometimes takes 2-3 weeks to wash out well). I was on doxepin (Sinequan) back in the early 80's and had a bad cold and was given some codeine cough syrup. Well, I went to work and got very dizzy and almost passed out after a single recommended dose of the codeine (orthostatic hypotension-low blood pressure-high heartrate).
>
> Celexa may have been what added to it as well. If you had all of those negative reactions to other antidepressants you could be bipolar. If so, it doesn't surprise me you had a run-in with the switchover to Celexa (you didn't mention the dosage). The first time I tried an SSRI (Prozac)-I started off with a full 20mg capsule every morning. Well...within about 10-days I had dilated pupils, sweating, insomnia, and mild nighttime hallucinations, had to drop the dose back quite drastically-and then I was Ok. But, I am bipolar and in retrospect that doesn't surprise me considering all of the sensitivity reactions I have had with a lot of antidepressants. You just may need much reduced dosages and you will be OK.
>
> Mitch

Hi Mitch,

Thanks for the reply. I had only started on 20mg. of Celexa and it was my second dose,I am also on 4mg of Gabitril. and as I said the 1mg of Ativan 3xday. It really scared me, especially after loosing my bowels and the horrid shaking. My pupils still dilate now and then even after a week and I'm NOT on anything but the Ativan and Gabitril. I am afraid to take my pain meds because the ER Doc said my reaction was due to the oxycodone. I thought she was being mean, because I do not abuse my pain meds and she was accusing me of being a druggie. I guess as it stands, there is nothing left for me to take as I don't do well on MAOI's either. I never want to go to the ER again.

Po_thang

 

Re: Toxic Serotonin Syndrome or narcotic reaction?

Posted by bookgurl99 on February 27, 2002, at 11:29:19

In reply to Re: Toxic Serotonin Syndrome or narcotic reaction? » Ritch, posted by Po_thang on February 27, 2002, at 1:37:13

hey po_thang,

i'm sorry that you're going through this right now.

i would suggest getting all your support people to know what you're going through. they should be able to remind you that the scary stuff is temporary. when all of those drugs rush out of your body, sudden mood changes are typical.

i'm also going to suggest doing some really positive things for yourself right now. eat healthy, but go ahead and give in to those carbohydrate cravings -- that's your brain looking for material to build seratonin with. Also, avoid watching or reading the news or anything negative. Instead, dig out your positive, favorite music, some good books, and comedy videos. Even treating yourself to a nice room with a couple lit candles and some relaxing music can help you focus on soothing thoughts and work through the pain.

Good luck, and remember, I'm praying for ya.

 

Re: Toxic Serotonin Syndrome or narcotic reaction? » bookgurl99

Posted by Po_thang on February 27, 2002, at 11:40:43

In reply to Re: Toxic Serotonin Syndrome or narcotic reaction?, posted by bookgurl99 on February 27, 2002, at 11:29:19

> hey po_thang,
>
> i'm sorry that you're going through this right now.
>
> i would suggest getting all your support people to know what you're going through. they should be able to remind you that the scary stuff is temporary. when all of those drugs rush out of your body, sudden mood changes are typical.
>
> i'm also going to suggest doing some really positive things for yourself right now. eat healthy, but go ahead and give in to those carbohydrate cravings -- that's your brain looking for material to build seratonin with. Also, avoid watching or reading the news or anything negative. Instead, dig out your positive, favorite music, some good books, and comedy videos. Even treating yourself to a nice room with a couple lit candles and some relaxing music can help you focus on soothing thoughts and work through the pain.
>
> Good luck, and remember, I'm praying for ya.

Thanks so much for your support. it's odd but I do not have any pain since coming off the Serzone, none. I'm also not craving anything. I just have a bad headache and still some dizziness. I feel a bit de-personalized (that's going away too) but not at all depressed. Seems as though I lucked out on the med withdrawal. :)

 

Re: Toxic Serotonin Syndrome or narcotic reaction? » Po_thang

Posted by disney4 on October 9, 2002, at 13:44:10

In reply to Re: Toxic Serotonin Syndrome or narcotic reaction? » Ritch, posted by Po_thang on February 27, 2002, at 1:37:13

> > > My Doc tapered my meds Serzone, Elavil and Ativan for 3 days then started Celexa and Xanax. I had been on those meds for four years. On the second day of Celexa (I also have neuropothy pain) took an oxycodone and had uncontrollable shaking within 10 mins. and ended up in ER, dilated pupils, could not talk, could not make legs move was released after 6 hours. Now off all meds cold turkey except Ativan. Did I have Toxic Serotonin Syndrome or bad reaction to oxycodone? I'm not getting an answer from my Doc. I'm very sensitive to meds and Serzone is the only one I had never reacted too. Even the Elavil caused insomnia. Any advice? I am also having anti-depressant withdrawals, how long is this going to last?
> >
> > Hi,
> >
> > If you had only tapered tricyclic antidepressants (the Elavil) for "three days"-you probably hadn't gotten rid of too much of it (sometimes takes 2-3 weeks to wash out well). I was on doxepin (Sinequan) back in the early 80's and had a bad cold and was given some codeine cough syrup. Well, I went to work and got very dizzy and almost passed out after a single recommended dose of the codeine (orthostatic hypotension-low blood pressure-high heartrate).
> >
> > Celexa may have been what added to it as well. If you had all of those negative reactions to other antidepressants you could be bipolar. If so, it doesn't surprise me you had a run-in with the switchover to Celexa (you didn't mention the dosage). The first time I tried an SSRI (Prozac)-I started off with a full 20mg capsule every morning. Well...within about 10-days I had dilated pupils, sweating, insomnia, and mild nighttime hallucinations, had to drop the dose back quite drastically-and then I was Ok. But, I am bipolar and in retrospect that doesn't surprise me considering all of the sensitivity reactions I have had with a lot of antidepressants. You just may need much reduced dosages and you will be OK.
> >
> > Mitch
>
> Hi Mitch,
>
> Thanks for the reply. I had only started on 20mg. of Celexa and it was my second dose,I am also on 4mg of Gabitril. and as I said the 1mg of Ativan 3xday. It really scared me, especially after loosing my bowels and the horrid shaking. My pupils still dilate now and then even after a week and I'm NOT on anything but the Ativan and Gabitril. I am afraid to take my pain meds because the ER Doc said my reaction was due to the oxycodone. I thought she was being mean, because I do not abuse my pain meds and she was accusing me of being a druggie. I guess as it stands, there is nothing left for me to take as I don't do well on MAOI's either. I never want to go to the ER again.
>
> Po_thang

Hi,

I had Serotonin Syndrome about two years ago from a combination of Luxox and tegretol, which push each other. I was so ill, but the Dr on call just thought I had a high tegretol level, so he had the level checked, and it came back slightly elevated. In retrospect, I know I had Serotonin Syndrome, and was not treated for it, other than stopping the meds. What did they give you for it?

 

Re: Toxic Serotonin Syndrome or narcotic reaction?

Posted by worrier on November 6, 2002, at 21:33:49

In reply to Re: Toxic Serotonin Syndrome or narcotic reaction? » Po_thang, posted by disney4 on October 9, 2002, at 13:44:10

> > > > My Doc tapered my meds Serzone, Elavil and Ativan for 3 days then started Celexa and Xanax. I had been on those meds for four years. On the second day of Celexa (I also have neuropothy pain) took an oxycodone and had uncontrollable shaking within 10 mins. and ended up in ER, dilated pupils, could not talk, could not make legs move was released after 6 hours. Now off all meds cold turkey except Ativan. Did I have Toxic Serotonin Syndrome or bad reaction to oxycodone? I'm not getting an answer from my Doc. I'm very sensitive to meds and Serzone is the only one I had never reacted too. Even the Elavil caused insomnia. Any advice? I am also having anti-depressant withdrawals, how long is this going to last?
> > >
> > > Hi,
> > >
> > > If you had only tapered tricyclic antidepressants (the Elavil) for "three days"-you probably hadn't gotten rid of too much of it (sometimes takes 2-3 weeks to wash out well). I was on doxepin (Sinequan) back in the early 80's and had a bad cold and was given some codeine cough syrup. Well, I went to work and got very dizzy and almost passed out after a single recommended dose of the codeine (orthostatic hypotension-low blood pressure-high heartrate).
> > >
> > > Celexa may have been what added to it as well. If you had all of those negative reactions to other antidepressants you could be bipolar. If so, it doesn't surprise me you had a run-in with the switchover to Celexa (you didn't mention the dosage). The first time I tried an SSRI (Prozac)-I started off with a full 20mg capsule every morning. Well...within about 10-days I had dilated pupils, sweating, insomnia, and mild nighttime hallucinations, had to drop the dose back quite drastically-and then I was Ok. But, I am bipolar and in retrospect that doesn't surprise me considering all of the sensitivity reactions I have had with a lot of antidepressants. You just may need much reduced dosages and you will be OK.
> > >
> > > Mitch
> >
> > Hi Mitch,
> >
> > Thanks for the reply. I had only started on 20mg. of Celexa and it was my second dose,I am also on 4mg of Gabitril. and as I said the 1mg of Ativan 3xday. It really scared me, especially after loosing my bowels and the horrid shaking. My pupils still dilate now and then even after a week and I'm NOT on anything but the Ativan and Gabitril. I am afraid to take my pain meds because the ER Doc said my reaction was due to the oxycodone. I thought she was being mean, because I do not abuse my pain meds and she was accusing me of being a druggie. I guess as it stands, there is nothing left for me to take as I don't do well on MAOI's either. I never want to go to the ER again.
> >
> > Po_thang
>
> Hi,
>
> I had Serotonin Syndrome about two years ago from a combination of Luxox and tegretol, which push each other. I was so ill, but the Dr on call just thought I had a high tegretol level, so he had the level checked, and it came back slightly elevated. In retrospect, I know I had Serotonin Syndrome, and was not treated for it, other than stopping the meds. What did they give you for it?
> Hi,
First time poster...didn't know there were so many of us out there. I was given paxil for panic attacks by my primary care doc and seemed o.k at 10mg/day. After a couple of weeks on 20mg/day the hell began...sweating, extreme panic ,nausea,tremors,etc. followed by a trip to the ER where I was given xanx. My dr. said to expect "breakthrough anxiety" and to increase to 30mg paxil/day. Did that...what a mistake. Finally went to a psychiatrist who took me off the paxil and suggested Xanax and time would stop the "serotonin storm", Six months later I am better but still not myself. Anyone had this last this long? Any sugestions?


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